Sequence Specific Capture

MagVigen™ - Streptavidin magnetic nanoparticle beads enable convenient capture of specific DNA sequence from biological samples, such as tissue lysate, whole blood and plasma samples. Captured DNA can be used in downstream applications such as NGS and clinical diagnosis. The figure below shows sequence specific DNA capture from human blood using MagVigen™-Streptavidin magnetic nanoparticle beads and biotin-CD19-targeted DNA probes.

MagVigen™ magnetic nanoparticle beads have smaller nanoparticle size, hence higher surface area and higher binding capacity. Smaller quantity of magnetic beads solid material is needed to achieve same capture capacity of targets compared to other magnetic beads on market. As shown in the following figure, much less MagVigen™-streptavidin magnetic nanoparticle beads are needed when compared to competitor's magnetic bead – streptavidin conjugates for sequence specific DNA capture. The smaller pellet size allows less buffer volume for elution, providing a higher concentration of target molecule solution for more sensitive downstream applications, such as NGS or DNA diagnosis. The smaller nanoparticle size, higher binding capacity, and unique surface chemistry prepared using NVIGEN’s proprietary technology make our MagVigen™ magnetic nanoparticle beads ideal for molecular and cellular purification and enrichment from complex biological samples. Shown in the following figure is for sequence specific DNA capture from fresh human whole blood samples using streptavidin conjugated magnetic beads and biotin-DNA probe. The competitor’s magnetic beads show severe aggregation. MagVigen™ magnetic beads enable a much cleaner magnetic capture result with much smaller pellet size and negligible aggregation for DNA extraction from whole blood samples.

Competitor's MagVigen™-Streptavidin.
The left side, competitor's; right side, MagVigen-Streptavidin.

Sequence specific DNA capture from whole blood samples.

  • Capture specific DNA molecules directly from sample solutions
  • Compatible with downstream applications (NGS, clinical diagnostics)
  • Smaller beads -> higher binding capacity -> less elution volume -> Higher DNA concentration
  • Better for probing protein-DNA interactions

Name Application Cat# Price(1ml) Add to cart
MagVigen™ - Streptavidin DNA Capture Include MagVigen™-Streptavidin nanoparticles 61002 $211
MagVigen™ - Streptavidin DNA Capture Kit Include MagVigen™-Streptavidin nanoparticles, wash buffer, blocking solution, capture solution. K61002 $240

MagVigen™ Protein A/G Nanoparticles - Product sheet 1

MagVigen™ Protein A/G nanoparticles are ideal for antibody purification and immunoprecipitation assays...
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MagVigen™ Streptavidin Nanoparticles - Product sheet 2

MagVigen™ Streptavidin magnetic nanoparticles can universally bind to any biotinylated biomolecules ...
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MagVigen™ - anti-FLAG Nanoparticles - Product sheet 3

MagVigen™ - anti-FLAG nanoparticles are ideal for the purification of FLAG tagged recombinant proteins ...
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MyQuVigen™ - anti-mouse IgG,
emi 635 nm - Product sheet 4

MyQuVigen™ nanoparticles are unique combination of SPIO and quantum dots ...
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MagVigen™ - Streptavidin DNA Capture - Product sheet 5

MagVigen™ Streptavidin DNA Capture nanoparticles can be used to capture specific RNA or DNA sequences directly from solution....
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